Table 5.

Gene Expression Pattern Induced by Screened Medicinal Ligands

Ligands	Gene Expression Pattern	% Age Inhibition or Modulation	Function of Gene in Ewing’s Sarcoma	Reference
Sorbifolin	E2F5 ↓	81.7% Suppression	Increases Tumor cell division	(Schwentner et al., 2015)
	STEAP1 ↓	75.2% Suppression	Stimulate Invasive phenotypes formations	(Grunewald et al., 2012)
	NOTCH1 ↑	82.4% Modulation	Downregulation of NOTCH1 pathway reduces tumor cell apoptosis	(Di Muccio et al., 2005)
1,7-dihydroxy-3-methylanthracene- 9.10-dione	CTSD ↓	94.4% Suppression	Promotes Cell metastasis	(Gemoll et al., 2015)