Table 1.
Features | Total | HPV (n=447) | p16 staining (n=238) | ||||
---|---|---|---|---|---|---|---|
Negative | Positive | P | Negative | Positive | P | ||
n (%) | n (%) | n (%) | n (%) | n (%) | |||
Age (year) | 0.577 | 0.456 | |||||
≤ 51 year | 206 (46.5) | 201 (97.5) | 5 (2.5) | 70 (69.3) | 31 (30.7) | ||
> 51 year | 241 (53.5) | 233 (96.6) | 8 (3.4) | 101 (73.7) | 36 (26.3) | ||
Tumor size | 0.82 | 0.022 | |||||
I | 28 (6.2) | 28 (100.0) | 0 (0.0) | 14 (93.3) | 1 (6.6) | ||
II | 195 (43.6) | 189 (96.0)) | 6 (4.0) | 92 (76.6) | 28 (23.4) | ||
III | 54 (12.4) | 51 (94.4) | 3 (5.6) | 20 (55.5) | 16 (44.5) | ||
IV | 160 (35.8) | 156 (97.5) | 4 (2.5) | 44 (68.8) | 20 (31.2) | ||
Stage | 0.549 | 0.076 | |||||
I | 17 (4.6) | 17 (100.0) | 0 (0.0) | 8 (80.0) | 2 (20.0) | ||
II | 146 (45.4) | 141 (96.6) | 5 (3.4) | 99 (76.7) | 30 (23.3) | ||
III | 225 (36.9) | 217 (96.4) | 8 | 57 (65.5) | 30 (34.5) | ||
IV | 59 (13.1) | 59 (100.0) | 0 (0.0) | 7 (58.3) | 5 (41.7) | ||
Grade | 0.097 | 0.009 | |||||
I | 10 (2.5) | 10 (100.0) | 0 (0.0) | 5 (62.5) | 3 (37.5) | ||
II | 151 (33.9) | 143 (95.0) | 8 (5.0) | 69 (82.2) | 13 (17.8) | ||
III | 284 (63.3) | 279 (98.2) | 5 (1.8) | 97 (65.5) | 51 (34.5) | ||
TIL (%) | 0.809 | 0.002 | |||||
<30 | 218 (54.9) | 211 (96.8) | 7 (3.2) | 96 (81.4) | 22 (18.6) | ||
≥30 | 179 (45.1) | 174 (97.2) | 5 (2.8) | 73 (62.9) | 43 (37.1) | ||
Histology | 0.003 | 0.145 | |||||
Ductal | 400 (89.5) | 392 (98.0) | 8 (2.0) | 71.8 | 58 (28.3) | ||
Lobulillar | 25 (5.6) | 22 (88.0) | 3 (12.0) | 14 (87.5) | 2 (12.5) | ||
Other | 22 (4.9) | 20 (90.9) | 2 (9.1) | 9 (56.3) | 7 (41.2) | ||
Phenotype | 0.181 | 0.021 | |||||
Luminal-A | 69 (15.7) | 65 (15.0) | 4 (30.8) | 37 (82.2) | 8 (17.8) | ||
Luminal-B | 236 (53.8) | 230 (97.5) | 6 (2.5) | 95 (71.9) | 37 (28.1) | ||
HER-2 | 66 (15.0) | 64 (97.0) | 2 (3.0) | 20 (80.0) | 5 (20) | ||
TNBC | 68 (15.5) | 67 (98.5) | 1 (1.5) | 18 (51.4) | 17 (48.6) | ||
p16 | 0.017 | ||||||
Negative | 171 (71.8) | 166 (97.1) | 5 (2.9) | - | - | ||
Positive | 67 (28.2) | 60 (89.5) | 7 (10.5) | - | - |
TNBC, triple negative breast cancer; TIL, Tumor Infiltrating Lymphocytes; P.value<0.05