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. 2022 May;23(5):1679–1685. doi: 10.31557/APJCP.2022.23.5.1679

Table 4.

Differences in Bax, Bcl-2, and Bax/Bcl-2 Ratio Protein Expression before Induction Phase Chemotherapy in Pediatric ALL

Clinical
characteristic
Outcome (n=17)
Bax Mean (SD) Bcl-2 Mean (SD) Bax/Bcl Ratio Mean (SD)
Age
1-10 years old 20.9 (23.16) 23.8 (24.62) 2.70 (3.444)
>10 years old 14.4 (7.37) 17.2 (15.70) 1.49 (1.145)
Gender
Boys 18.3 (20.85) 19.2 (18.16) 2.59 (3.317)
Girls 30.7 (28.87) 49.1 (47.80) 1.73 (2.273)
Hepatomegaly
Presence 21.4 (23.86) 23.0 (25.90) 2.92 (3.497)
Absence 14.4 (8.33) 21.5 (11.87) 1.08 (1.066)
Splenomegaly
Presence 14.9 (6.72) 25.3 (26.07) 3.66 (4.775)
Absence 22.4 (25.96) 21.2 (22.39) 1.85 (1.841)
Lymphadenopathy
Presence 12.4 (6.75) 16.9 (22.14) 3.41 (4.030)
Absence 21.4 (23.98) 24.4 (23.87) 2.21 (2.992)
Hemoglobin level
Hb < 8 g/dL 24.6 (29.51) 21.6 (25.18) 3.5 (1.81)
Hb >8 g/dL 16.4 (13.69) 23.5 (22.75) 1.8 (2.79)
Trombocyte count
<150 x103/µL 19.5 (23.15) 19.1 (20.27) 3.0 (3.59)
>150 x103/µL 19.1 (20.27) 31.1 (29.35) 1.2 (1.31)
Leukocyte count
<4 x103/µL 28.3 (31.41) 28.5 (28.66) 3.1 (3.82)
4-20 x103/µL 10.1 (1.73) 25.8 (24.89) 1.1 (1.39)
>20 x103/µL 17.6 (7.96) 11.4 (6.26) 2.9 (3.61)
Neutrophil count
<500/µL 24.0 (16.76) 28.3 (27.79) 2.54 (3.301)
>500/µL 13.7 (7.11) 14.6 (11.15) 2.41 (3.225)

the statistical test used is the Mann Whitney U test, except for the number of leukocytes using the Kolmogorov-Smirnov Test.