Table 4.
Differences in Bax, Bcl-2, and Bax/Bcl-2 Ratio Protein Expression before Induction Phase Chemotherapy in Pediatric ALL
| Clinical characteristic |
Outcome (n=17) | ||
|---|---|---|---|
| Bax Mean (SD) | Bcl-2 Mean (SD) | Bax/Bcl Ratio Mean (SD) | |
| Age | |||
| 1-10 years old | 20.9 (23.16) | 23.8 (24.62) | 2.70 (3.444) |
| >10 years old | 14.4 (7.37) | 17.2 (15.70) | 1.49 (1.145) |
| Gender | |||
| Boys | 18.3 (20.85) | 19.2 (18.16) | 2.59 (3.317) |
| Girls | 30.7 (28.87) | 49.1 (47.80) | 1.73 (2.273) |
| Hepatomegaly | |||
| Presence | 21.4 (23.86) | 23.0 (25.90) | 2.92 (3.497) |
| Absence | 14.4 (8.33) | 21.5 (11.87) | 1.08 (1.066) |
| Splenomegaly | |||
| Presence | 14.9 (6.72) | 25.3 (26.07) | 3.66 (4.775) |
| Absence | 22.4 (25.96) | 21.2 (22.39) | 1.85 (1.841) |
| Lymphadenopathy | |||
| Presence | 12.4 (6.75) | 16.9 (22.14) | 3.41 (4.030) |
| Absence | 21.4 (23.98) | 24.4 (23.87) | 2.21 (2.992) |
| Hemoglobin level | |||
| Hb < 8 g/dL | 24.6 (29.51) | 21.6 (25.18) | 3.5 (1.81) |
| Hb >8 g/dL | 16.4 (13.69) | 23.5 (22.75) | 1.8 (2.79) |
| Trombocyte count | |||
| <150 x103/µL | 19.5 (23.15) | 19.1 (20.27) | 3.0 (3.59) |
| >150 x103/µL | 19.1 (20.27) | 31.1 (29.35) | 1.2 (1.31) |
| Leukocyte count | |||
| <4 x103/µL | 28.3 (31.41) | 28.5 (28.66) | 3.1 (3.82) |
| 4-20 x103/µL | 10.1 (1.73) | 25.8 (24.89) | 1.1 (1.39) |
| >20 x103/µL | 17.6 (7.96) | 11.4 (6.26) | 2.9 (3.61) |
| Neutrophil count | |||
| <500/µL | 24.0 (16.76) | 28.3 (27.79) | 2.54 (3.301) |
| >500/µL | 13.7 (7.11) | 14.6 (11.15) | 2.41 (3.225) |
the statistical test used is the Mann Whitney U test, except for the number of leukocytes using the Kolmogorov-Smirnov Test.