Table 4.
Differences in Bax, Bcl-2, and Bax/Bcl-2 Ratio Protein Expression before Induction Phase Chemotherapy in Pediatric ALL
Clinical characteristic |
Outcome (n=17) | ||
---|---|---|---|
Bax Mean (SD) | Bcl-2 Mean (SD) | Bax/Bcl Ratio Mean (SD) | |
Age | |||
1-10 years old | 20.9 (23.16) | 23.8 (24.62) | 2.70 (3.444) |
>10 years old | 14.4 (7.37) | 17.2 (15.70) | 1.49 (1.145) |
Gender | |||
Boys | 18.3 (20.85) | 19.2 (18.16) | 2.59 (3.317) |
Girls | 30.7 (28.87) | 49.1 (47.80) | 1.73 (2.273) |
Hepatomegaly | |||
Presence | 21.4 (23.86) | 23.0 (25.90) | 2.92 (3.497) |
Absence | 14.4 (8.33) | 21.5 (11.87) | 1.08 (1.066) |
Splenomegaly | |||
Presence | 14.9 (6.72) | 25.3 (26.07) | 3.66 (4.775) |
Absence | 22.4 (25.96) | 21.2 (22.39) | 1.85 (1.841) |
Lymphadenopathy | |||
Presence | 12.4 (6.75) | 16.9 (22.14) | 3.41 (4.030) |
Absence | 21.4 (23.98) | 24.4 (23.87) | 2.21 (2.992) |
Hemoglobin level | |||
Hb < 8 g/dL | 24.6 (29.51) | 21.6 (25.18) | 3.5 (1.81) |
Hb >8 g/dL | 16.4 (13.69) | 23.5 (22.75) | 1.8 (2.79) |
Trombocyte count | |||
<150 x103/µL | 19.5 (23.15) | 19.1 (20.27) | 3.0 (3.59) |
>150 x103/µL | 19.1 (20.27) | 31.1 (29.35) | 1.2 (1.31) |
Leukocyte count | |||
<4 x103/µL | 28.3 (31.41) | 28.5 (28.66) | 3.1 (3.82) |
4-20 x103/µL | 10.1 (1.73) | 25.8 (24.89) | 1.1 (1.39) |
>20 x103/µL | 17.6 (7.96) | 11.4 (6.26) | 2.9 (3.61) |
Neutrophil count | |||
<500/µL | 24.0 (16.76) | 28.3 (27.79) | 2.54 (3.301) |
>500/µL | 13.7 (7.11) | 14.6 (11.15) | 2.41 (3.225) |
the statistical test used is the Mann Whitney U test, except for the number of leukocytes using the Kolmogorov-Smirnov Test.