Table 3.

Incidence of ≥ Grade3 adverse events

	UD N = 58 (%)	ED N = 304 (%)	OD N = 324 (%)	Two-sided P by trend test
Hematological
Neutropenia	3 (5.2%)	46 (15.2%)*	53 (16.4%)	0.080
Anemia	0	5 (1.6%)	13 (4.0%)	0.024
Thrombocytopenia	0	0	6 (1.9%)	0.018
Non-hematological
Fatigue	0	4 (1.3%)	9 (2.8%)	0.082
Diarrhea	0	7 (2.3%)	18 (5.6%)	0.008
Nausea	0	1 (0.3%)	2 (0.6%)	0.448
Stomatitis	0	1 (0.3%)	7 (2.2%)	0.030
Anorexia	0	7 (2.3%)	28 (8.6%)	< 0.0001

*One patient is missing