Table 4.
Multivariable cox-regression analysis of risk of mortality during 5-year follow-up in all histologically confirmed gastric non-cardia adenocarcinoma patients and stratified by surgical treatment
| Covariate | Category | Gastric non- cardia adenocarcinoma | |
|---|---|---|---|
| Number of patients (%) | HR (95% CI) | ||
| All patients | |||
| Calendar period | 1987–1991 | 4486 (24.0) | 1.08 (1.02–1.15) |
| 1992–1996 | 3720 (19.9) | 1.02 (0.96–1.08) | |
| 1997–2001 | 3135 (16.8) | 0.97 (0.91–1.03) | |
| 2002–2006 | 2928 (15.6) | 1.02 (0.95–1.08) | |
| 2007–2011 | 2552 (13.6) | 0.97 (0.91–1.04) | |
| 2012–2016 | 1892 (10.1) | 1 (Reference) | |
| Age | > 50 | 1325 (7.1) | 1 (Reference) |
| 50–59 | 2243 (12.0) | 1.03 (0.95–1.12) | |
| 60–69 | 4197 (22.4) | 1.14 (1.06–1.22) | |
| 70–79 | 5910 (31.6) | 1.37 (1.28–1.47) | |
| 80–89 | 4398 (23.5) | 1.90 (1.77–2.04) | |
| 90 + | 640 (3.4) | 2.92 (2.64–3.24) | |
| Sex | Female | 8864 (47.4) | 1 (Reference) |
| Male | 9849 (52.6) | 1.07 (1.03–1.10) | |
| CCI | 0 | 12,007 (64.2) | 1 (Reference) |
| 1 | 4058 (21.7) | 1.01 (0.97–1.05) | |
| 2 | 1717 (9.2) | 1.12 (1.06–1.18) | |
| 3 + | 931 (5.0) | 1.22 (1.14–1.32) | |
| Surgery | |||
| Calendar period | 1987–1991 | 2051 (24.7) | 1.58 (1.41–1.77) |
| 1992–1996 | 1817 (21.9) | 1.40 (1.24–1.56) | |
| 1997–2001 | 1505 (18.1) | 1.21 (1.07–1.36) | |
| 2002–2006 | 1293 (15.6) | 1.19 (1.06–1.35) | |
| 2007–2011 | 995 (12.0) | 1.03 (0.90–1.16) | |
| 2012–2016 | 632 (7.6) | 1 (Reference) | |
| Age | > 50 | 728 (8.8) | 1 (Reference) |
| 50–59 | 1186 (14.3) | 1.01 (0.89–1.14) | |
| 60–69 | 2129 (25.7)) | 1.11 (1.00–1.24) | |
| 70–79 | 2777 (33.5) | 1.37 (1.23–1.52) | |
| 80–89 | 1410 (17.0) | 1.83 (1.63–2.05) | |
| 90 + | 63 (0.8) | 2.94 (2.22–3.88) | |
| Sex | Female | 3865 (46.6) | 1 (Reference) |
| Male | 4428 (53.4) | 1.10 (1.05–1.16) | |
| CCI | 0 | 5515 (66.5) | 1 (Reference) |
| 1 | 1805 (21.8) | 1.13 (1.06–1.21) | |
| 2 | 653 (7.9) | 1.25 (1.13–1.38) | |
| 3 + | 320 (3.9) | 1.55 (1.36–1.77) | |
| No surgery | |||
| Calendar period | 1987–1991 | 2435 (23.4) | 1.05 (0.98–1.13) |
| 1992–1996 | 1903 (18.3) | 1.13 (1.05–1.22) | |
| 1997- 2001 | 1630 (15.6) | 1.13 (1.05–1.22) | |
| 2002–2006 | 1635 (15.7) | 1.16 (1.08–1.25) | |
| 2007–2011 | 1557 (14.9) | 1.07 (0.99–1.15) | |
| 2012–2016 | 1260 (12.1) | 1 (Reference) | |
| Age | > 50 | 597 (5.7) | 1 (Reference) |
| 50–59 | 1057 (10.1) | 1.03 (0.93–1.15) | |
| 60–69 | 2068 (19.8) | 1.13 (1.02 -1.24) | |
| 70–79 | 3133 (30.1) | 1.28 (1.17–1.40) | |
| 80–89 | 2988 (28.7) | 1.44 (1.33–1.58) | |
| 90 + | 577 (5.5) | 1.65 (1.47–1.86) | |
| Sex | Female | 4999 (48.0) | 1 (Reference) |
| Male | 5421 (52.0) | 1.03 (0.99–1.08) | |
| CCI | 0 | 6492 (62.3) | 1 (Reference) |
| 1 | 2253 (21.6) | 0.95 (0.91–1.00) | |
| 2 | 1064 (10.2) | 0.99 (0.93–1.06) | |
| 3 + | 611 (5.9) | 0.97 (0.89–1.05) | |
CCI Charlson Comorbidity Index