Table 5.
Multivariable cox-regression analysis of risk of mortality during 5-year follow-up in all histologically confirmed gastric cardia adenocarcinoma patients and stratified by surgical treatment
| Covariate | Category | Gastric cardia adenocarcinoma | |
|---|---|---|---|
| Number of patients (%) | HR (95% CI) | ||
| All patients | |||
| Calendar period | 1987–1991 | 677 (18.7) | 1.49 (1.30–1.71) |
| 1992–1996 | 676 (18.7) | 1.36 (1.19–1.55) | |
| 1997–2001 | 657 (18.2) | 1.27 (1.11–1.45) | |
| 2002–2006 | 551 (15.2) | 1.24 (1.08–1.43) | |
| 2007–2011 | 612 (16.9) | 1.13 (0.98–1.29) | |
| 2012–2016 | 444 (12.3) | 1 (Reference) | |
| Age | > 50 | 265 (7.3) | 1 (Reference) |
| 50–59 | 523 (14.5) | 0.91 (0.78–1.07) | |
| 60–69 | 929 (25.7) | 0.98 (0.84–1.14) | |
| 70–79 | 1126 (31.1) | 1.13 (0.97–1.30) | |
| 80–89 | 678 (18.7) | 1.59 (1.36–1.87) | |
| 90 + | 96 (2.7) | 2.03 (1.59–2.60) | |
| Sex | Female | 1085 (30.0) | 1 (Reference) |
| Male | 2532 (70.0) | 1.05 (0.97–1.14) | |
| CCI | 0 | 2222 (61.4) | 1 (Reference) |
| 1 | 817 (22.6) | 1.07 (0.98–1.17) | |
| 2 | 375 (10.4) | 1.26 (1.12–1.42) | |
| 3 + | 203 (5.6) | 1.33 (1.14–1.55) | |
| Surgery | |||
| Calendar period | 1987–1991 | 270 (20.5) | 2.22 (1.72–2.86) |
| 1992–1996 | 280 (21.2) | 1.82 (1.42–2.35) | |
| 1997–2001 | 271 (20.5) | 1.48 (1.14–1.90) | |
| 2002–2006 | 171 (13.0) | 1.17 (0.88–1.54) | |
| 2007–2011 | 176 (13.3) | 0.86 (0.65–1.15) | |
| 2012–2016 | 152 (11.5) | 1 (Reference) | |
| Age | > 50 | 117 (8.9) | 1 (Reference) |
| 50–59 | 225 (17.0) | 0.84 (0.63–1.10) | |
| 60–69 | 409 (31.0) | 1.00 (0.78–1.29) | |
| 70–79 | 445 (33.7) | 1.19 (0.92–1.52) | |
| 80–89 | 118 (8.9) | 1.45 (1.06–1.97) | |
| 90 + | 6 (0.5) | 2.50 (1.09–5.77) | |
| Sex | Female | 361 (27.3) | 1 (Reference) |
| Male | 959 (72.7) | 1.22 (1.05–1.42) | |
| CCI | 0 | 905 (68.6) | 1 (Reference) |
| 1 | 283 (21.4) | 1.01 (0.85–1.19) | |
| 2 | 94 (7.1) | 1.13 (0.87–1.46) | |
| 3 + | 38 (2.9) | 1.30 (0.85–1.85) | |
| No surgery | |||
| Calendar period | 1987–1991 | 407 (17.7) | 1.34 (1.14–1.57) |
| 1992–1996 | 396 (17.2) | 1.36 (1.16–1.59) | |
| 1997–2001 | 386 (16.8) | 1.42 (1.21–1.66) | |
| 2002–2006 | 380 (16.5) | 1.28 (1.09–1.50) | |
| 2007–2011 | 436 (19.0) | 1.20 (1.03–1.40) | |
| 2012–2016 | 292 (12.7) | 1 (Reference) | |
| Age | > 50 | 148 (6.4) | 1 (Reference) |
| 50–59 | 298 (13.0) | 0.90 (0.73–1.10) | |
| 60–69 | 520 (22.6) | 0.96 (0.80–1.16) | |
| 70–79 | 681 (29.6) | 1.02 (0.85–1.23) | |
| 80–89 | 560 (24.4) | 1.12 (0.93–1.36) | |
| 90 + | 90 (3.9) | 1.24 (0.95–1.64) | |
| Sex | Female | 724 (31.5) | 1 (Reference) |
| Male | 1573 (68.5) | 0.98 (0.90–1.08) | |
| CCI | 0 | 1317 (57.3) | 1 (Reference) |
| 1 | 534 (23.2) | 1.07 (0.96–1.19) | |
| 2 | 281 (12.2) | 1.14 (1.00–1.31) | |
| 3 + | 165 (7.2) | 1.11 (0.94–1.32) | |
CCI Charlson Comorbidity Index