Table 5.
Correlations between baseline biomarkers vs baseline and longitudinal change in DAT specific binding ratios among LRRK2 G2019S carriers.
| Correlation with baseline mean striatum SBR | Correlation with 2-year percent change from baseline in mean striatum SBR | |||||
|---|---|---|---|---|---|---|
| Baseline Biomarker | N Obs | Spearman’s Rho | p value | N Obs | Spearman’s Rho | p value |
| Polygenic risk score | 155 | −0.10 | 0.2304 | 115 | 0.03 | 0.7513 |
| Serum urate | 140 | 0.02 | 0.8513 | 101 | −0.01 | 0.8880 |
| CSF Abeta (quintile) | 143 | −0.06 | 0.4876 | 105 | 0.13 | 0.2016 |
| CSF tau (quintile) | 143 | 0.02 | 0.7903 | 105 | 0.15 | 0.1296 |
| CSF p-tau (quintile) | 143 | 0.07 | 0.3942 | 105 | 0.14 | 0.1511 |
| Serum NfL | 135 | 0.13 | 0.1342 | 114 | −0.03 | 0.7724 |
| Urine total di-18:1-BMP | 164 | −0.15 | 0.0523 | 119 | −0.06 | 0.5067 |
| Urine total di-22:6-BMP | 164 | −0.28 | 0.0003* | 119 | -0.03 | 0.7298 |
| Urine 2,2-di-22:6-BMP | 164 | −0.27 | 0.0005* | 119 | −0.04 | 0.6932 |
Correlation coefficients and p values were computed using Spearman partial rank-order correlations controlling for age and sex (correlations with polygenic risk score also controlled for the first five principal components of the genetic data; correlations with 2-year change in DAT also controlled for mean striatum SBR at baseline).
DAT dopamine transporter. SBR specific binding ratio. CSF cerebrospinal fluid. NfL neurofilament light chain. BMP bis(monoacylglycerol)phosphate. *Significance level for comparisons is p < 0.0056 (after Bonferroni correction).