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Functional properties of mouse anti-PD-1 monoclonal antibodies.
| Mouse antibodies | PD-1 binding activity, EC50 (ng/ml) | PD-1/PD-L1 binding blockade activity, IC50 (ng/ml) | Binding kinetics | ||
|---|---|---|---|---|---|
| kon (1/Ms) | koff (1/s) | KD (nM) | |||
| mCUSB0103 | 34.42 | 1,005 | 3.52E + 05 | 5.45E-04 | 1.549 |
| mCUSB0123 | 39.23 | 2,678 | 3.68E + 05 | 5.41E-04 | 1.468 |
| mCUSB0124 | 73.08 | 11,170 | 9.37E + 04 | 1.67E-03 | 1.784 |
| mCUSB0126 | 27.83 | 891 | 3.28E + 05 | 6.09E-04 | 1.855 |
| mCUSB0129 | 38.51 | 1,651 | 3.62E + 05 | 3.46E-04 | 0.954 |
