| Clopidogrel, which is frequently used to prevent ischemic stroke, may cause treatment resistance and lead to recurrence of stroke. |
| Overall, 206 participants who received clopidogrel treatment were enrolled in the study. The participants were further divided into the modification (39 patients) and no modification (167 patients) groups. |
| Modification based on the platelet reactivity unit (PRU) cutoff value significantly improved the outcomes of the per protocol set population after adjusting for severe cerebral artery stenosis. |
| Clopidogrel therapy with a PRU cutoff value of 190 may be considered to improve outcomes. |
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