Fig. 1.

Crystal structure of the TTR protein dimer highlighting the loci of the three variants. The light blue and green colors indicate the individual monomers of the TTR dimer. The green TTR monomer is labeled with select variants. The red text indicates the position of the TTR variants reclassified from VUS to VLP (D58H, A65V, and T80I) and nearby pathogenic variants are shown in black. TTR, transthyretin; VLP variant likely pathogenic, VUS variant of uncertain significance