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. Author manuscript; available in PMC: 2022 Oct 23.
Published in final edited form as: Respir Physiol Neurobiol. 2022 Apr 18;302:103912. doi: 10.1016/j.resp.2022.103912

Fig. 3.

Fig. 3.

Alveolar-arterial (A-a) gradient values prior to administration of morphine (Pre), 15 min after injection of morphine sulfate (2 mg/kg, i.v.) (M15:D0) and subsequently 15 min after each of two injections of vehicle or D-cysteine ethyl ester (D-CYSee, 100 μmol/kg, iv) (Panel A) or vehicle or D-cystine dimethyl ester (D-CYSdime, 100 μmol/kg, iv) (Panel B) (M30:D15 and M60:D45, respectively) in isoflurane-anesthetized rats. Panel C shows the arithmetic changes in A-a gradient from the morphine values elicited by injections of vehicle, D-CYSee, or D-CYSdime. The data are presented as mean ± SEM. There were 5 rats in each group. * P < significant difference from Pre values. †P < 0.05, D-CYSdime versus vehicle.