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. Author manuscript; available in PMC: 2022 Oct 23.

Published in final edited form as: Respir Physiol Neurobiol. 2022 Apr 18;302:103912. doi: 10.1016/j.resp.2022.103912

Table 4.

Arterial blood-gas chemistry and Alveolar-arterial gradients.

		Sampling Periods
Parameter	Treatment	Pre	Morphine	Dose 1	Dose 2
pH	Vehicle	7.449 ± 0.005	7.326 ± 0.012 ^*	7.321 ± 0.015 ^*	7.324 ± 0.014 ^*
	D-cysteine	7.447 ± 0.006	7.327 ± 0.14 ^*	7.322 ± 0.008 ^*	7.327 ± 0.15 ^*
	D-cystine	7.446 ± 0.006	7.325 ± 0.011 ^*	7.328 ± 0.013 ^*	7.331 ± 0.013 ^*
pCO₂	Vehicle	35.5 ± 0.2	45.7 ± 0.6 ^*	45.7 ± 0.4 ^*	45.8 ± 0.5 ^*
	D-cysteine	35.8 ± 0.2	46.3 ± 1.1 ^*	46.5 ± 0.8^*	46.6 ± 0.6^*
	D-cystine	36.0 ± 0.3	45.6 ± 1.0 ^*	45.4 ± 1.0^*	42.1 ± 1.3 ^*,^†
pO₂	Vehicle	92.9 ± 0.8	69.7 ± 0.9 ^*	69.2 ± 0.7 ^*	70.7 ± 1.6 ^*
	D-cysteine	93.5 ± 0.8	68.9 ± 1.0 ^*	69.0 ± 1.1 ^*	69.6 ± 1.0 ^*
	D-cystine	92.7 ± 0.8	68.8 ± 2.7 ^*	69.2 ± 2.3 ^*	79.9 ± 2.1 ^*,^†
sO₂	Vehicle	100.2 ± 0.7	83.2 ± 0.6 ^*	83.1 ± 0.5 ^*	81.8 ± 1.1 ^*
	D-cysteine	100.5 ± 1.4	82.7 ± 0.7 ^*	81.3 ± 1.1 ^*	81.7 ± 0.6 ^*
	D-cystine	98.9 ± 0.5	81.4 ± 1.3 ^*	81.1 ± 1.2^*	87.7 ± 0.4 ^*,^†
A-a	Vehicle	17.4 ± 0.7	29.3 ± 0.5 ^*	29.7 ± 2 ^*	28.2 ± 1.9 ^*
	D-cysteine	16.4 ± 0.7	29.4 ± 2.0 ^*	29.1 ± 1.6^*	28.3 ± 1.1 ^*
	D-cystine	17.0 ± 1.0	30.2 ± 2.2 ^*	30.1 ± 1.7^*	23.0 ± 1.1 ^*,^†

The data are presented as mean ± SEM. There were 5 rats in each group.

^*

P < significant effect of morphine.

^†

P < 0.05, Dose 2 drug versus vehicle.