Table 2.
The role of the TREM-1 signaling pathway in CNS diseases
| Disease | Study Models | Molecules in the TREM-1 Signaling Pathway | Conclusions | Refs. |
|---|---|---|---|---|
| Ischemic Stroke | Rat MCAO model/in vitro | ROS, NLRP3 | TREM-1 induced microglia activation, oxidative stress and pyroptosis | [84] |
| Mouse MCAO model/in vitro | SYK | TREM-1 induced inflammation and pyroptosis | [85] | |
| Subarachnoid hemorrhage | Mouse | SYK | TREM-1 promoted microglia activation and neutrophil infiltration, induced neuroinflammation | [95] |
| Rat | TLR4 | TREM-1 interacted with the TLR4 pathway to promote EBI | [94] | |
| Rat | p38MAPK/MMP-9, ZO-1 | TREM-1 was involved in blood‒brain barrier disruption and brain oedema | [99] | |
| Mouse | NLRP3 | TREM-1 induced microglia pyroptosis and neutrophil infiltration, promoted neuroinflammation, and led to neuronal apoptosis and degeneration | [100] | |
| Intracerebral hemorrhage | Mouse | PKCδ/CARD 9 | TREM-1 regulated microglia polarization and induced neuroinflammation | [59] |
| Parkinson’s disease | Zebrafish | MAPK | TREM-1 inhibition improved locomotor impairment, suppressed inflammation | [110] |
| Rat | MAPK | TREM-1 inhibition inhibited microglia and astrocyte hyperactivation | [110] | |
| In vitro | MAPK | TREM-1 inhibition suppressed inflammation and enhanced autophagy | [110] | |
| Alzheimer’s disease | Mouse | Aβ | TREM-1 promoted microglia phagocytosis of Aβ, alleviated AD neuropathology and improved AD-related spatial cognitive deficits | [54] |
| Spinal cord injury | Mouse/in vitro | HO-1 | TREM-1 promoted microglia activation, induced inflammation and oxidative stress | [127] |
| Spinal cord ischemia‒reperfusion injury | Mouse/in vitro | SYK | TREM-1 mediated neuronal apoptosis | [128] |