Fig. 4.

circ_0025033 silencing inhibited ovarian cancer cell malignant behaviors via targeting hsa_miR-370-3p. A–K SKOV3 and A2780 cells were transfected with si-NC, si-circ_0025033, si-circ_0025033 + anti-miR-NC, or si-circ_0025033 + anti-hsa_miR-370-3p. A Expression of hsa_miR-370-3p measured by qRT-PCR. B and C Cell proliferation detected using CCK-8 assay and EdU assay. D–F Apoptosis, invasion, and angiogenesis ability assessed using flow cytometry, transwell, and tube formation assays. G and H Western blot analysis of c-Myc and MMP9. I–K Glutamine assay kit, α-ketoglutarate assay kit, and glutamate assay kit were utilized to detect glutamine consumption, α-ketoglutarate production, and glutamate production, respectively. **P < 0.01, ***P < 0.001, ****P < 0.0001