Table 6.
Effect size of TG/HDL-C on Pre-DM in prespecified and exploratory subgroups
| Characteristic | No of participants | OR (95%CI) | P value | P for interacion |
|---|---|---|---|---|
| Age, years | < 0.001 | |||
| < 30 | 40094 | 1.169 (1.011, 1.353) | 0.036 | |
| 30–40 | 50062 | 1.265 (1.168, 1.369) | < 0.001 | |
| 40–50 | 32980 | 1.238 (1.158, 1.323) | < 0.001 | |
| 50–60 | 15748 | 1.145 (1.066, 1.230) | < 0.001 | |
| 60–70 | 6767 | 1.000 (0.907, 1.102) | 0.999 | |
| ≥ 70 | 7512 | 1.057 (0.963, 1.161) | 0.240 | |
| Gender | < 0.001 | |||
| Female | 85861 | 1.366 (1.287, 1.450) | < 0.001 | |
| Male | 67302 | 1.109 (1.065, 1.155) | < 0.001 | |
| BMI (kg/m2) | 0.012 | |||
| < 18.5 | 18005 | 0.928 (0.726, 1.187) | 0.552 | |
| ≥ 18.5, < 24 | 121856 | 1.253 (1.206, 1.301) | < 0.001 | |
| ≥ 24 | 13302 | 1.153 (1.066, 1.247) | 0.004 | |
| ALT (U/L) | 0.005 | |||
| ≤ 40 | 144562 | 1.296 (1.138, 1.475) | < 0.001 | |
| > 40 | 8601 | 1.190 (1.149, 1.232) | < 0.001 | |
| GLB (g/L) | 0.348 | |||
| < 30 | 89724 | 1.202 (1.148, 1.258) | < 0.0001 | |
| ≥ 30 | 63439 | 1.163 (1.105, 1.224) | < 0.0001 |
Note 1: Above model adjusted for age, sex, BMI, ALT, AST, GGT, ALB, GLB, DBIL, BUN, Scr, UA, TC, LDL-C, TB
Note 2: In each case, the model is not adjusted for the stratification variable
OR odds ratios, CI confidence, Ref reference, TG/HDL-C triglyceride-to-high-density lipoprotein cholesterol ratio