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. 2022 Oct 22;19:22. doi: 10.1186/s12977-022-00608-1

Fig. 2.

Fig. 2

Clinical considerations for choosing between INSTIs. aCabotegravir has a higher genetic barrier to resistance than first generation INSTIs (RAL and EVG) with limited cross-resistance to these latter INSTIs; however, CAB may have a lower genetic barrier to resistance than other second generation INSTIs (DTG and BIC). BIC bictegravir, CAB cabotegravir, DTG dolutegravir, EVG elvitegravir, HBV hepatitis B virus, RAL raltegravir, STR single tablet regimen, TB tuberculosis