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. 2022 Oct 23;22:326. doi: 10.1186/s12935-022-02742-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Development of the prognostic model based on FRGs in the training cohort. A A forest plot showing the FRGs associated with OS according to univariable cox analysis. B Variable selection by lasso regression analysis with 1000 bootstrap replicates. C LASSO coefficients of FRGs. D The protein–protein interactions among the model related proteins and the other proteins. Green, protein interaction; orange, activation; red, activate expression; purple, phosphorylation; grey pink, indirect relation; blue, inhibition. The circle size represents the number of interacting proteins that are linked to a specific protein (the bigger the circle size, the more interacted proteins)