Table 1.

Baseline characteristics of the training and validation cohorts

Characteristics	Training cohort GSE136337 (n = 426)	Validation cohort GSE24080 (n = 559)	Validation cohort GSE57317 (n = 55)
Gender
Male	261 (61%)	337 (60%)	–
Female	165 (39%)	222 (40%)	–
Age (years)
≤ 65	307 (72%)	432 (77%)	–
> 65	119 (28%)	127 (23%)	–
Albumin (g/dL)
< 3.5	88 (21%)	77 (14%)	–
≥ 3.5	337 (79%)	482 (86%)	–
NA	2	–	–
β2M (mg/L)
< 3.5	187 (45%)	319 (57%)	–
3.5–5.4	111 (26%)	120 (22%)	–
≥ 5.5	121 (29%)	119 (21%)	–
NA	7	1	–
LDH (U/L)
≤ 250	398 (94%)	509 (91%)	–
> 250	24 (6%)	50 (9%)	–
NA	4	–	–
ISS
I	168 (40%)	294 (53%)	–
II	135 (32%)	144 (26%)	–
III	121 (28%)	120 (21%)	–
NA	2	1	–
RISS
I	83 (20%)	–	–
II	270 (64%)	–	–
III	66 (16%)	–	–
NA	7	–	–
Risk
Low	213 (50%)	280 (50%)	28 (51%)
High	213 (50%)	279 (50%)	27 (49%)
Transplant(s)
< 3	331 (78%)	–	–
≥ 3	95 (22%)	–	–
Del(13q)
TRUE	77 (18%)	–	–
FALSE	349 (82%)	–	–
Del(11q)
TRUE	8 (2%)	–	–
FALSE	418 (98%)	–	–
Del(17p)
TRUE	15 (4%)	–	–
FALSE	411 (96%)	–	–
Del(16q)
TRUE	14 (3%)	–	–
FALSE	412 (97%)	–	–
Del(1p32)
TRUE	85 (20%)	–	–
FALSE	341 (80%)	–	–
Myc(8q24)
TRUE	20 (5%)	–	–
FALSE	406 (95%)	–	–
t (11,14)
TRUE	22 (5%)	–	–
FALSE	404 (95%)	–	–
t (12,14)
TRUE	1 (1%)	–	–
FALSE	425 (99%)	–	–
t (14,16)
TRUE	1 (1%)	–	–
FALSE	425 (99%)	–	–
t (14,20)
TRUE	1 (1%)	–	–
FALSE	425 (99%)	–	–
Hyperdiploid
TRUE	85 (20%)	–	–
FALSE	341 (80%)	–	–
Survival status
Alive	243 (57%)	387 (69%)	43 (78%)
Dead	183 (43%)	172 (31%)	12 (22%)