Table 2.
The univariate and multivariate analyses of overall survival according to GEMIN6 expression and other prognostic factors.
| Characteristics | Total (n) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | ||
| T stage (T3-4 vs. T1-2) | 523 | 2.317 (1.591-3.375) | <0.001 | 1.697 (1.029-2.799) | 0.038 |
| N stage (N1-3 vs. N0) | 510 | 2.601 (1.944-3.480) | <0.001 | 1.966 (1.332-2.901) | <0.001 |
| Pathologic stage (stage III-IV vs. stage I-II) | 518 | 2.664 (1.960-3.621) | <0.001 | 1.312 (0.828-2.080) | 0.247 |
| Primary therapy outcome (PR & SD & PD vs. CR) | 439 | 2.690 (1.918-3.771) | <0.001 | 2.308 (1.620-3.286) | <0.001 |
| Gender (male vs. female) | 526 | 1.070 (0.803-1.426) | 0.642 | ||
| Race (White vs. Asian & Black or African American) | 468 | 1.475 (0.902-2.411) | 0.121 | ||
| Age (>65 vs. ≤65) | 516 | 1.223 (0.916-1.635) | 0.172 | ||
| Smoker (yes vs. no) | 512 | 0.894 (0.592-1.348) | 0.591 | ||
| Number pack years smoked (≥40 vs. <40) | 363 | 1.073 (0.753-1.528) | 0.697 | ||
| GEMIN6 (high vs. low) | 526 | 1.529 (1.136-2.058) | 0.005 | 1.491 (1.063-2.092) | 0.021 |