FIG. 4.

Examining arrhythmogenic mechanisms in post-infarct hearts with pluripotent stem cell-derived cardiomyocyte (PSC-CM) transplantation. Colors indicate the sequence of activation (ms). Pacing to induce arrhythmia was delivered from sites marked with the white star. Transplantation of stem-cell-derived cardiomyocytes resulted in re-entrant arrhythmias (pathway traced with the white arrow), suggesting that the location of this cell therapy could be arrhythmogenic. Reproduced with permission from Yu et al., Sci. Rep. 9, 9238 (2019). Copyright 2019 Author(s), licensed under a Creative Commons Attribution (CC BY) license.⁶³