Table 2:

Peak oxygen uptake (VO₂) measurements at baseline and 6- and 12-month aerobic exercise and stretching interventions

		Aerobic exercise		Stretching		p-values
	Time	EMM	(95% CI)	EMM	(95% CI)	Group	Time	Group*Time
Peak oxygen uptake (mL·min−1)	Baseline	1.64	(1.56 to 1.72)	1.58	(1.50 to 1.66)	0.035	0.001	0.013
	6-month	1.76	(1.67 to 1.84)*†	1.59	(1.50 to 1.67)
	12-month	1.74	(1.66 to 1.83)*†	1.61	(1.53 to 1.70)
Peak oxygen uptake (ml·kg−1·min−1)	Baseline	22.9	(21.8 to 23.9)	21.5	(20.4 to 22.5)	0.001	<0.001	0.002
	6-month	25.0	(23.8 to 26.1)*†	21.7	(20.6 to 22.8)
	12-month	25.0	(23.9 to 26.1)*†	22.2	(21.1 to 23.3)
Body mass (kg)	Baseline	71.5	(67.1 to 75.9)	74.0	(69.6 to 78.4)	0.386	0.120	0.865
	6-month	70.9	(66.4 to 75.4)	73.7	(69.3 to 78.1)
	12-month	70.7	(66.2 to 75.1)	73.5	(69.1 to 77.9)
Peak heart rate (bpm)	Baseline	159	(155 to 163)	161	(156 to 165)	0.667	0.417	0.931
	6-month	161	(156 to 165)	162	(157 to 166)
	12-month	160	(156 to 165)	161	(157 to 165)
Peak respiratory exchange ratio	Baseline	1.17	(1.14 to 1.20)	1.16	(1.13 to 1.18)	0.843	0.049	0.063
	6-month	1.13	(1.10 to 1.16)	1.16	(1.13 to 1.19)
	12-month	1.14	(1.11 to 1.17)	1.13	(1.10 to 1.16)

Values are estimated marginal means (EMM), 95% confidence intervals (CI), and p-values calculated from the linear mixed model based on the intent-to-treat analysis. The models for peak oxygen uptake were adjusted for baseline age and sex. p<0.05 are bolded.

^*vs. baseline within the same group.

^†vs. stretching group at the same time point.