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. Author manuscript; available in PMC: 2023 Apr 14.
Published in final edited form as: Clin Cancer Res. 2022 Oct 14;28(20):4466–4478. doi: 10.1158/1078-0432.CCR-22-0384

Figure 5. HOXD13 binds active chromatin in EwS cells at intergenic and intronic regions and at EWS::ETS binding sites.

Figure 5.

A) Pie chart showing the genomic distribution of HOXD13 binding sites shared between CHLA10 and A673 cells. B) Bar chart summarizing shared binding sites and associated histone marks at these sites. C) Tornado plots depicting shared HOXD13 binding and the associated histone marks by genomic location. D) HOMER Motif analysis by genomic location for the shared HOXD13 binding sites. E) Venn diagrams showing the overlap between HOXD13 binding sites and published EWS::FLI1 binding sites in shared sites. Bar graphs depict genomic locations of shared HOXD13 and EWS::FLI1 bound sites. F) Representative CUT&RUN tracks of HOXD13 binding and associated histone marks at a direct target intronic region. G) Heatmaps depicting shared HOXD13 and EWS::FLI1 nearest genes negatively regulated by EWS::FLI1 after HOXD13 knockdown. H) Heatmaps depicting shared HOXD13 and EWS::FLI1 nearest genes negatively regulated by EWS::FLI1 after HOXD13 knockdown.