Table 4:

Rates and Risks of Outcomes at 1-Year Amongst those with an ICD-10 Claim of I35.0 in the Overall Medicare Dataset

Outcome	I35.0 Present (N = 402,559)	I35.0 Absent (N = 3,631,285)	Adjusted Hazard Ratio (95% CI)
All-cause mortality	13.6% (13.5%, 13.7%)	7.3% (7.3%, 7.3%)	1.33 (1.31, 1.34)
Heart failure hospitalization	1.8% (1.8%, 1.9%)	0.8% (0.8%, 0.8%)	1.37 (1.34, 1.41)
Aortic valve replacement	4.1% (4.1%, 4.2%)	0.1% (0.1%, 0.1%)	34.96 (33.74, 36.22)
Transcatheter aortic valve replacement	3.0% (3.0%, 3.1%)	0.1% (0.1%, 0.1%)	45.09 (42.97, 47.32)
Surgical aortic valve replacement	1.1% (1.1%, 1.1%)	0.1% (0.1%, 0.1%)	23.64 (22.35, 25.00)

Shown are the unadjusted rates (determined using Kaplan-Meier estimates) and 95% confidence intervals (in parentheses) of relevant outcomes amongst those with and without an ICD-10 claim of 135.0 in any position in the overall Medicare dataset (a complete sample of Medicare inpatient and outpatient claims, 2017–2019) at 1-year following baseline (3 months after the most recent echocardiogram). Additionally shown are the hazard ratios and 95% confidence intervals (in parentheses) for the occurrence of each outcome using the group without an I35.0 claim as reference, adjusting for age, sex, and all 27 Medicare Chronic Condition Warehouse variables. Aortic valve replacement refers to the receipt of either a transcatheter or surgical aortic valve replacement. Non-death outcomes are adjusted for the competing risk of death with event rates taken from cumulative incidence functions.