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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Circ Genom Precis Med. 2022 Sep 28;15(5):e003535. doi: 10.1161/CIRCGEN.121.003535

Figure 3:

Figure 3:

Pathway diagram of selected genes and pathways. Pathway diagram showing the relationship of selected genes and pathways in the analysis of effect-measure modification by OSA on genetic risk of CAD, using pathway-specific polygenic risk scores (PS-PRS) and gene-specific risk scores (GSRS). Risk inverting effect-measure modification by OSA on the VEGF KEGG pathway PS-PRS attained Bonferroni-corrected statistical significance (p<0.005) based on 10 pre-specified tests in the primary analysis. The GSRS for ARNT had nominally significant (p<0.05) risk-amplifying effect-measure modification by OSA. The HIF1 KEGG pathway contains additional genes and modules not shown, and partially overlaps the NFκB and TNF pathways. Estimated PS-PGRS effect modification for HIF-1, NFκB and TNF pathways did not meet nominal significance in primary analysis.