Table 1.
Sample characteristics
| OSA control | OSA case | |||
|---|---|---|---|---|
| N | 471,877 | 4,974 | ||
| Outcome: | ||||
| CAD, N (%) | 25,988 | (5.50) | 711 | (14.30) |
| Covariates: | ||||
| BMI (median [IQR]) | 26.67 | (24.09, 29.79) | 31.61 | (28.11, 36.39) |
| Age (median [IQR]) | 58 | (50.00, 63.00) | 58 | (51.00, 63.00) |
| Male (%) | 213,700 | (45.30) | 3,622 | (72.80) |
| Smoking (%) | ||||
| current | 36,568 | (7.70) | 519 | (10.40) |
| never | 259,572 | (55.00) | 2,162 | (43.50) |
| occasionally | 12,484 | (2.60) | 183 | (3.70) |
| previous | 163,253 | (34.60) | 2,110 | (42.40) |
| Self-reported white (%) | 397,269 | (84.20) | 4,054 | (81.50) |
| Genetic PC1 (mean (SD)) | −1.53 | (53.33) | 1.95 | (60.96) |
| Genetic PC2 (mean (SD)) | 0.5 | (27.38) | 0.21 | (27.29) |
| Genetic PC3 (mean (SD)) | −0.17 | (14.61) | 0.82 | (15.30) |
| Genetic PC4 (mean (SD)) | 0.13 | (10.32) | −0.2 | (12.07) |
| Genetic PC5 (mean (SD)) | 0.05 | (7.57) | 0.28 | (7.42) |
| BiLEVE genotype platform (%) | 48,528 | (10.30) | 619 | (12.40) |
| COPD (%) | 18,888 | (4.00) | 608 | (12.20) |
| Asthma (%) | 62,630 | (13.30) | 1,126 | (22.60) |
| Standardized PRS and PS-PRS Exposures: | ||||
| KEGG hsa04066 HIF1 (mean (SD)) | −0.0002 | 1.000 | −0.011 | 0.985 |
| KEGG hsa04370 VEGF (mean (SD)) | −0.0014 | 1.000 | 0.029 | 0.982 |
| KEGG hsa04064 NFκB (mean (SD)) | 0.0002 | 1.000 | 0.003 | 1.005 |
| KEGG hsa04668 TNF (mean (SD)) | 0.0002 | 1.000 | 0.015 | 1.017 |
| HIF1 core genes (mean (SD)) | 0.0018 | 1.000 | −0.016 | 0.999 |
| VEGF core genes (mean (SD)) | 0.0003 | 1.000 | −0.010 | 0.991 |
| NFκB core genes (mean (SD)) | 0.0011 | 1.000 | −0.015 | 1.006 |
| TNF core genes (mean (SD)) | −0.0009 | 1.000 | 0.001 | 0.992 |
| CAD PRS (mean (SD)) | 0.0000 | 0.998 | 0.034 | 1.015 |
| OSA genes (mean (SD)) | −0.0016 | 0.999 | −0.005 | 0.997 |
Outcome, covariate and polygenic risk score distributions by OSA status. OSA: Obstructive sleep apnea, CAD: coronary artery disease, BMI: body mass index, PC: principal component, COPD: chronic obstructive pulmonary disease, KEGG: Kyoto encyclopedia of genes and genomes, hsa: Homo sapiens pathway reference number, HIF1: hypoxia inducible factor 1, VEGF: vascular endothelial growth factor, NFκB: nuclear factor kappa- beta, TNF: tumor necrosis factor, PRS: polygenic risk score, PS-PRS: pathway-specific polygenic risk score.