Table 1:
Baseline Participant Characteristics
| Characteristics | Population (N=18) | 5HTTLPR:LALA genotype N=6 (33%) | 5HTTLPR:LS/SS genotype N=12 (67%) | p-value |
|---|---|---|---|---|
|
| ||||
| Age Mean (SD) | 27 (6.9) | 26.7 (6.56) | 27.5 (7.61) | 0.81 |
|
| ||||
| Male (No., %) | 12 (67%) | 4 (67%) | 8 (67%) | |
|
| ||||
| Average BMI (SD) | 24.9 (3.6) | 26.6 (1.85) | 24.1 (4.02) | 0.10 |
|
| ||||
| Educational Level | ||||
| ≥16 Years (No., %) | 14 (78%) | 4 (67%) | 10 (83%) | |
| <16 Years (No., %) | 4 (22%) | 2 (33%) | 2 (17%) | |
|
| ||||
| Average AUDIT Score (SD) | 8.6 (2.3) | 8.7 (1.03) | 8.5 (2.81) | 0.86 |
|
| ||||
| *Past 30 Days Drinking Measures | ||||
| Average DDD (SD) | 4.7 (1.8) | 5.6 (1.2) | 4.3 (1.92) | 0.11 |
| Average Binge Episodes (SD) | 7.3 (4.7) | 8.67 (3.27) | 6.67 (5.25) | 0.34 |
|
| ||||
| **Past 90 Days Other Drug Use | ||||
| Nicotine (No.) | 4 | 2 | 2 | |
| Marijuana (No.) | 7 | 2 | 5 | |
| Cocaine (No.) | 1 | 0 | 1 | |
|
| ||||
| †Average SERT mRNA levels (SD) | 1.1795 (0.08) | 1.2103 (0.07) | 1.1654 (0.08) | 0.06 |
|
| ||||
| EtG Levels: | ||||
| ≥LLOQ (No. of participants, %) | 1 (2%) | 1 (7%) | 0 (0%) | |
| 0-LLOQ (No. of participants, %) | 3 (7%) | 2 (14%) | 1 (3%) | |
| EtS Levels: | ||||
| ≥LLOQ (No. of participants, %) | 5 (11%) | 2 (14%) | 3 (9%) | |
| 0-LLOQ (No. of participants, %) | 1 (2%) | 0 (0%) | 1 (3%) | |
BMI – body mass index
*
calculated using standard drinks consumed in the 30 days prior to initial in-person screen
**
Number of participants who used other drugs (excluding alcohol) in the 90 days prior to initial in-person screen
†
all SERT mRNA levels were normalized by GAPDH mRNA (housekeeping gene) expression levels
SD – standard deviation.