TABLE 1.
Alcohol research which reports front‐loading‐like behavior
| Protocol | Species | Sex differences? | Citation | How is front‐loading calculated? |
|---|---|---|---|---|
| DID (20% EtOH vs. water) | B6 mice | No sex difference in front‐loading | Rhodes et al. (2007) | Assessment of sipper contacts in 30‐min bins |
| DID (20% EtOH vs. water) | B6 mice | N/A—males only | Linsenbardt and Boehm (2014) | Comparison to water group |
| DID (20% EtOH vs. water) | B6 mice | N/A—males only | Wilcox et al. (2014) | Intake in the early part of the session is compared with a later part of the session |
| DID (20% EtOH) | B6 mice | F w/ EtOH DID history front‐load more quinine‐adulterated alcohol than M | Bauer et al. (2021) | 30 min EtOH intake of EtOH‐history group compared with water‐history group |
| DID (20% EtOH vs. water) | B6 mice | N/A—males only | Salling et al. (2018) | Comparison to water group |
| DID (20% EtOH vs. water) | HAP1 mice | No interaction of sex. All graphs shown collapsed on sex | Linsenbardt and Boehm (2015) | Comparison to water group |
| DID (20% EtOH vs. water) | HAP2;3 mice | No interaction of sex. All graphs shown collapsed on sex | Ardinger et al. (2020) | Comparison to water group; comparison to flat distribution of intake |
| DID (20% EtOH vs. water) | HDID1, HDID2, and Hs‐Npt (progenitor) mice | No sex difference in front‐loading | Jensen et al. (2021) | Comparison of time to reach >80 mg/dl BEC (HDID1/2 vs. Hs‐Npt) |
| IA2BC (24‐h MWF, 20% EtOH and water) | Wistar rats | N/A—m2B ales only | Darevsky et al. (2019) | Comparison to flat distribution of intake |
| Operant self‐administration (FR1, FR3) | Wistar rats | F front‐load more than M in 30 min FR1 session; no sex differences observed in 30 or 15 min FR3 sessions | Flores‐Bonilla et al. (2021) | Intake in the early part of the session is compared with a later part of the session |
| Operant self‐administration (FR3) | Long‐Evans rats | N/A—males only | Jeanblanc et al. (2019) | Comparison of lever presses across different session lengths: 1 h, 30 min, and 15 min |
| IA2BC (24‐h MWF, 20% EtOH and water) | Sprague–Dawley rats | No sex difference in first hour intake on last 3 days | Quadir et al. (2022) | Assessment of first hour intake |
| IA2BC (2‐h: 15% EtOH and water) following vapor CIE or air only | B6 mice | N/A—males only | Griffin et al. (2009) | Comparison of lick pattern: CIE vs. air control |
| IA2BC (24‐h MWF, 20% EtOH and water) | Long‐Evans rats | N/A—males only | Carnicella et al. (2009) | Assessment of first hour intake |
Abbreviations: 2BC, two‐bottle choice; B6, C57BL/6J; CIE, chronic intermittent access; DID, drinking‐in‐the‐dark; FR1/3, fixed ratio 1/3; HAP, high alcohol‐preferring; HDID, high drinking‐in‐the‐dark; IA2BC, intermittent access to 2‐bottle choice; MWF, monday, wednesday, and friday.