Table 3.
Phenotypes in Carriers of Pathogenic/Likely Pathogenic Variants Associated with Brugada Syndrome
| Carriers (N=4) | Noncarriers (N=20) | P value | |
|---|---|---|---|
| Demographics | |||
| Age, years | 66.5 ± 15.5 | 66.6 ± 13.7 | NA |
| Female | 3 (75%) | 15 (75%) | |
| Genetic ancestry | |||
| European | 3 (75%) | 15 (75%) | |
| African | 1 (25%) | 5 (25%) | |
| Electrocardiogram | |||
| Individuals with electrocardiogram | 3 (75%) | 20 (100%) | 0.2 |
| Type 1 Brugada pattern | 0 | 0 | NA |
| Other findings | |||
| PR interval, ms | 258 ± 69 | 162 ± 21 | 0.009 |
| 1st degree atrioventricular block + left axis deviation | 2 (67%) | 1 (5%) | 0.03 |
| QRS duration, ms | 113 ± 3 | 97 ± 19 | 0.06 |
| Syncope | 2 (50%) | 4 (20%) | 0.3 |
| Atrial fibrillation/flutter | 2 (50%) | 6 (30%) | 0.6 |
| Nonsustained/sustained ventricular tachycardia | 0 | 3 (15%) | 1 |
| Permanent pacemaker | 2 (50%) | 2 (10%) | 0.1 |
| Implantable cardioverter-defibrillator | 0 | 1 (5%) | 1 |
| Obstructive coronary artery disease | 1 (25%) | 12 (60%) | 0.3 |
Continuous measures are described as mean ± standard deviation and are compared using the Wilcoxon rank-sum test. Categorical variables are described as N (%) and are compared using Fisher’s exact test. P values in bold indicate p <0.05. NA, not applicable.