. Author manuscript; available in PMC: 2023 Oct 1.

Published in final edited form as: Circ Genom Precis Med. 2022 Sep 22;15(5):e003675. doi: 10.1161/CIRCGEN.121.003675

Table 7.

Arrhythmia-related Genes Studied

Inherited Primary Arrhythmia Syndromes
Diseases	Associated Genes
Brugada Syndrome	ABCC9^, CACNA1C^, CACNA2D1, CACNB2, GPD1L, HCN4, KCND3, KCNE3, KCNE5, KCNJ8, PKP2^, RANGRF, SCN1B, SCN2B, SCN3B, SCN5A^^†, SCN10A
Catecholaminergic Polymorphic Ventricular Tachycardia	CASQ2, RYR2^^†, TRDN^^†
Familial Atrial Fibrillation	ABCC9^, KCNA5, KCNH2^, KCNJ2^, KCNQ1^, LMNA^, RYR2^, SCN5A^*
Long QT Syndrome	AKAP9, ANK2, CACNA1C^^†, CALM1, CALM2, CALM3, CAV3, KCNE1, KCNE2, KCNH2^^†, KCNJ2^^†, KCNJ5, KCNQ1^^†, SCN4B, SCN5A^, SNTA1, TRDN^
Short QT Syndrome	CACNA1C^, KCNH2^, KCNJ2^, KCNQ1^
Arrhythmogenic Cardiomyopathies
Diseases	Associated Genes
Arrhythmogenic Right Ventricular Cardiomyopathy	DSC2, DSG2, DSP^^†, JUP, PKP2^^†, RYR2^, SCN5A^
Hypertrophic Cardiomyopathy	ACTC1, MYBPC3, MYH7, MYL2, MYL3, TNNI3, TNNT2, TPM1
Other Arrhythmogenic Cardiomyopathies	ABCC9^^†, CTNNA3, DES, DSP^, FLNC, KCNH2^, KCNQ1^, LDB3, LMNA^^†, PLN, SCN5A^, TMEM43, TRPM4

Genes associated with >1 disease

^†

Most common disease association for genes associated with >1 disease