Skip to main content
. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: J Am Chem Soc. 2022 Oct 6;144(41):18861–18875. doi: 10.1021/jacs.2c05030

Figure 1. HDAC10 inhibitors, substrates, and design concept for a selective HDAC10 inhibitor.

Figure 1.

Far left box: Dual HDAC10/6 binders.(7, 8) Middle left box: Selected acetamides, which are good substrates of HDAC10. Middle right box: Selected acetamides, which are poor substrates of HDAC10. Far right box: Concept to merge the structures of SAHA (9) and 10 (9, 10) to create aza-SAHA derivatives, which should produce a potent and selective HDAC10 chemical probe. kcat/KM values are reported for hHDAC10 and taken from Hai et al. (11).