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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: J Am Chem Soc. 2022 Oct 6;144(41):18861–18875. doi: 10.1021/jacs.2c05030

Figure 10. HDAC10 inhibition suppresses rescue by N8-AcSPD under polyamine-limiting conditions.

Figure 10.

A: DKFZ-748 prevents growth rescue by N8-AcSPD from DMFO treatment in HeLa S3 cells dose-dependently. B: HPLC quantification of polyamines in treated HeLa S3 cells. Cells were pre-treated with DKFZ-748 for 24 h, followed by co-treatment with DMFO and N8-AcSPD for 96 h. Data is pooled from at least two biological replicates, each performed in technical triplicates, and represented as mean with standard error.