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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: J Am Chem Soc. 2022 Oct 6;144(41):18861–18875. doi: 10.1021/jacs.2c05030

Table 1.

pIC50 valuesa of γ-amino hydroxamic acids.

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a

pIC50 values are the mean of two replicates, each determined by four-parameter non-linear regression analysis with eight dose levels in triplicate with HDAC Glo assayb or FRET assayc.

d

Mean of at least three individual experiments.

e

Curve fit analysis not convergent at 100 μM. SF (selectivity factor) = 10(pIC50(HDAC10) − pIC50(HDAC6 or 1)) rounded to two significant figures. Activity profile for the best HDAC10 inhibitors are highlighted in bold. For an extended version of this table with 95% confidence intervals, see Table S2.