Table 3.
Multivariable Models Predicting Guideline Directed Medical Therapy Use
| Odds Ratio for Use (95% CI) | ||||
|---|---|---|---|---|
| Predictor | Beta Blocker | HF Beta Blocker | ACEi/ARB/ARNI | MRA |
| Age (per 10 year increase) | 0.74 (0.61–0.91) | 0.81 (0.73–0.90) | 0.70 (0.60–0.82) | 0.95 (0.83–1.08) |
| Male | 0.67 (0.39–1.16) | 0.96 (0.71–1.30) | 0.77 (0.59–1.18) | 1.47 (1.00–2.16) |
| BMI (per 5 kg/m2 increase) | 1.02 (0.84–1.24) | 1.04 (0.94–1.16) | 1.06 (0.91–1.24) | 1.15 (1.02–1.29) |
| Diabetes | 1.30 (0.70–2.38) | 0.89 (0.64–1.24) | 1.59 (0.96–2.62) | 1.10 (0.74–1.65) |
| Cerebrovascular disease | 0.75 (0.38–1.48) | 0.82 (0.53–1.28) | 0.78 (0.44–1.36) | 0.64 (0.34–1.20) |
| Hypertension | 1.75 (0.98–3.12) | 1.01 (0.72–1.43) | 1.96 (1.24–3.11) | 1.26 (0.84–1.90) |
| Coronary artery disease | 1.31 (0.75–2.31) | 1.07 (0.77–1.48) | 1.33 (0.85–2.08) | 0.81 (0.55–1.21) |
| COPD | 0.66 (0.37–1.17) | 0.73 (0.52–1.03) | 0.64 (0.41–1.01) | 1.04 (0.67–1.60) |
| eGFR (per 10 mL/min increase) | 1.07 (0.96–1.19) | 1.00 (0.96–1.03) | 1.09 (1.00–1.19) | 0.96 (0.88–1.03) |
| EF (per 5% increase) | 0.97 (0.82–1.16) | 0.85 (0.77–0.94) | 0.99 (0.86–1.14) | 0.90 (0.81–1.01) |
| Seen in HF Clinic | 4.72 (2.11–10.56) | 3.44 (2.46–4.80) | 4.46 (2.47–8.04) | 2.70 (1.92–3.79) |
| Inpatient diagnosis of HF | 1.08 (0.66–1.78) | 0.75 (0.57–1.00) | 1.18 (0.79–1.75) | 0.74 (0.53–1.05) |
BMI= body mass index, BP= blood pressure, COPD= chronic obstructive pulmonary disease; EF= ejection fraction; eGFR= estimated glomerular filtration rate; HF= heart failure