Table 1 |. Summary of the in vivo haemodynamics data.
Clinical metrics for the diagnostic evaluation and staging of AS, with corresponding thresholds of mild, moderate and severe AS from the literature31,36–38, and actuation-volume ranges of the biomimetic soft robotic sleeve used to recapitulate each metric.
| Mild | Moderate | Severe | ||||
|---|---|---|---|---|---|---|
| Physiology metrics | Sleeve actuation (mL) | Physiology metrics | Sleeve actuation (mL) | Physiology metrics | Sleeve actuation (mL) | |
| iEOA (cm2/m2) | > 0.85 | < 2.0 | 0.6 – 0.85 | 2.2 – 2.8 | < 0.6 | > 2.8 |
| ΔPmax (mmHg) | < 40 | < 2.6 | 40 – 65 | 2.6 – 3.4 | > 65 | > 3.4 |
| ΔPmean (mmHg) | < 20 | < 2.6 | 20 – 40 | 2.6 – 3.7 | > 40 | > 3.7 |
| AS jet velocity (m/s) | < 3.0 | < 2.6 | 3.0 – 4.0 | 2.6 – 3.6 | > 4.0 | > 3.6 |
| ELI (cm2/m2) | > 1.0 | < 2.3 | 0.5 – 1.0 | 2.3 – 3.3 | < 0.5 | > 3.3 |
| ZVA (mmHg m−1m2) | < 3.5 | < 2.6 | 3.5 – 5.0 | 2.6 – 3.3 | > 5.0 | > 3.3 |