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. Author manuscript; available in PMC: 2022 Oct 24.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2022 Sep 24;57(4):443–460. doi: 10.1080/10409238.2022.2121804

Figure 2.

Figure 2.

Schematics of two SNARE assembly pathways and their associated characteristic intermediates, the 1:1 syntaxin-1:SNAP-25 t-SNARE complex and the Munc18–1:syntaxin-1:VAMP2 template complex. Additional intermediates and their structural models and transition kinetics are shown in Figures 1(E) and 4(A).