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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: J Immunol. 2022 Sep 19;209(9):1691–1702. doi: 10.4049/jimmunol.2200320

Figure 5. Antigen-specific CD8 T cell differentiation in visceral tissues after LCMV infections.

Figure 5.

(A) Frequency of H-2Db/gp33-specific CD8 T cells that were present in the extravascular space (protected from intravenous CD8α antibodies) were measured in 2 barrier mucosal tissues and kidneys at 30 days post-infection. Plots are gated on live CD8β+ T cells (CD8a IV-). SI-IEL: small intestine intraepithelial lymphocytes and FRT: female reproductive tract. (B) Enumeration of H-2Db/gp33-specific CD8 T cells in indicated organs. (C) Representative flow plots depicting expression of number of inhibitory receptors, memory markers as well as resident memory T cell marker on H-2Db/gp33-specific CD8 T cells in small intestine IEL. Plots are gated on tetramer+ live CD8β+ T cells. Data are representative of two separate experiments with n=3 mice/group per experiment. Bars indicate mean ± SEM. ***p <0.0001, ns-not significant. Kruskal Wallis one-way ANOVA with Dunn’s multiple comparison test.