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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: J Membr Biol. 2022 Aug 16;255(4-5):375–383. doi: 10.1007/s00232-022-00259-5

Figure 3. Cryo-EM structure of the human Cav1 8S complex reveals it is a tightly packed disc composed of 11 copies of Cav1.

Figure 3.

(a) Cryo-EM density map of the Cav1 8S complex at 3.5 Å resolution. A single Cav1 protomer is highlighted in magenta. (b) Side view of the complex. (c) Secondary structure model of the complex shows it is composed of tightly packed α-helices and contains a central β-barrel. (d) Side view of the secondary structure map showing the dimensions of the complex. Adapted from Porta, JC, B Han, A Gulsevin, JM Chung, Y Peskova, S Connolly, HS McHaourab, J Meiler, E Karakas, AK Kenworthy and MD Ohi (2022). Molecular architecture of the human caveolin-1 complex. Sci Adv 8(19): eabn7232.