FIGURE 3.

Methods used to qualify disorders for inclusion in BeginNGS™. GTRx, Genome‐to‐Treatment virtual acute management guidance system (Figure 4). Group A, disorders for which the Delphi panel consensus was that the Phase ii criteria were met. Group B, disorders for which the natural history was not yet well understood or for which early treatment was not yet known to improve outcome but that were retained for prospective clinical study. ICU, intensive care unit; NBS, newborn screening; rWGS, rapid whole genome sequencing