Table 1.
Characteristics of participants.
Osteoporosis/solid cancer | Total | BP/Dmab users | Users of other drugs | P value | |
---|---|---|---|---|---|
Patients | 92 | 60 | 32 | ||
(Women) | (82) | (56) | (26) | ||
Osteoporosis medication users | 81 | Oral BPs | 37 | 21 | |
Injection BPs | 11 | ||||
Dmab | 12 | ||||
a Age (years, mean ± SD) | 74.6 ± 10.8 | 77.5 ± 7.9 | 68.3 ± 13.4 | ∗∗ | |
Median | 76 | 78 | 70 | 3.13E-05 | |
Oral BPs | 77.1 ± 8.9 | ||||
Injection BPs | 77.8 ± 4.0 | ||||
Dmab | 78.5 ± 7.9 | ||||
b Number of extracted teeth | 78 | 70 | 8 | ∗∗ | |
(Patients) | (47) | (40) | (7) | 8.54E-05 | |
Upper | 32 | 29 | 3 | ||
Lower | 46 | 41 | 5 | ||
Period of tooth extraction from first visit | 96.2 ± 96.4 days | 103.8 ± 99.8 days | 43.1 ± 42.7 days | ||
Median | 69 | 89 | 33 | ||
Period of follow-up after tooth extraction | 122.7 ± 182.0 days | 122.6 ± 170.0 days | 123.9 ± 268.7 days | ||
Median | 42 | 45 | 28 | ||
MRONJ | 11 patients | Referral clinic, 9 patients | 0 | ||
Our clinic, 2 patients (3.3%) |
BP, bisphosphonate; Dmab, denosumab; SD, standard deviation; MRONJ, medication-related osteonecrosis of the jaw.
∗∗P < 0.01.
Student's t-test.
Mann–Whitney U test.