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. 2022 Oct 23;13:6318. doi: 10.1038/s41467-022-34096-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A scheme of treatment in an HT-1080 xenograft tumor model with IKE. Athymic nude mice were injected subcutaneously with indicated ALDH1B1-knockdown (ALDH1B1^KD) or EIF4E-knockdown (EIF4E^KD) HT-1080 cells for 7 days and then treated with IKE (40 mg/kg, i.p., once every other day) at day 7 for 2 weeks. b Tumor volumes were calculated weekly (n = 6 mice/group; two-way ANOVA with Tukey’s multiple comparisons test; data are presented as mean ± SD). c Photographs of isolated tumors on day 14 after treatment. d–i The levels of 4HNE (d) and PTGS2 mRNA (e) in isolated tumors, serum HMGB1 (f), caspase-3 activity (g), ALDH1B1 protein (h), and EIF4E protein (i) in isolated tumors at day 14 after treatment were assayed (n = 6 mice/group; two-way ANOVA with Tukey’s multiple comparisons test; data were presented as mean ± SD).