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. 2022 Oct 23;13:6318. doi: 10.1038/s41467-022-34096-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Athymic nude mice were injected subcutaneously with HT-1080 cells for 7 days and then given intratumoral treatment with 4HNE (5 mg/kg, once every other day) in the absence or presence of ZVAD-FMK (5 mg/kg, once every other day) or liproxstatin-1 (5 mg/kg, once every other day) at day 7 for 2 weeks. Tumor volumes were calculated weekly (n = 6 mice/group; two-way ANOVA with Tukey’s multiple comparisons test; data were presented as mean ± SD). b Photographs of isolated tumors on day 14 after treatment. c–h The levels of PTGS2 mRNA (c), serum HMGB1 (d), and caspase-3 activity in isolated tumors (e); body weight (f), serum ALT (g), and serum BUN (h) at day 14 after treatment were assayed (n = 6 mice/group; one-way ANOVA with Tukey’s multiple comparisons test; data were presented as mean ± SD). i Athymic nude mice were injected subcutaneously with indicated HT-1080 cells for 7 days and then given intratumoral treatment with 4HNE (5 mg/kg, once every other day) at day 7 for 2 weeks. Tumor volumes were calculated weekly (n = 6 mice/group; two-way ANOVA with Tukey’s multiple comparisons test; data are presented as mean ± SD). j, k The levels of PTGS2 mRNA in tumor (j) and serum HMGB1 (k) at day 14 after treatment were assayed (n = 6 mice/group; one-way ANOVA with Tukey’s multiple comparisons test; data were presented as mean ± SD).