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. 2022 Aug 18;7(5):100560. doi: 10.1016/j.esmoop.2022.100560

Table 4.

First-line therapy among stage IV NSCLC adenocarcinoma patients with a positive molecular test result

Type of therapy
Number of patients %
Molecular test
Treatment administered
First-line targeted therapy
 EGFR positive 558
 Targeted treatment administereda 457 81.9
 Afatinib 99 21.7
 Erlotinib 65 14.2
 Gefitinib 197 43.1
 Osimertinib 94 20.6
 Other 14 3.1
 No drug administered 101 18.1
 ALK gene rearrangement 46
 Targeted treatment administeredb 30 65.2
 Alectinib 21 70.0
 Ceritinib 4 13.3
 Crizotinib 5 16.7
 Other 2 6.7
 No drug administered 16 34.8
 ROS1 gene rearrangement 13
 Targeted treatment administered 4 30.8
 Alectinib 0 0
 Ceritinib 0 0
 Crizotinib 4 100.0
 Other 0 0
 No drug administered 9 69.2
a

10 cases took two different drugs, one case took three different drugs.

b

Two cases took two different drugs.