Table 2.

Univariate and multivariate analysis of the parameters included in the baseline model

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.03 (1.01-1.04)	<0.005	1.03 (1.02-1.05)	<0.005
CA19-9	1.00 (1.00-1.00)	0.065	1.00 (1.00-1.00)	0.201
CRP	1.08 (1.06-1.11)	<0.005	1.08 (1.05-1.11)	<0.005
M0	0.53 (0.35-0.81)	<0.005	0.56 (0.33-0.95)	0.030
M1 (HEP)	1.79 (1.31-2.44)	<0.005	1.26 (0.86-1.87)	0.236
NLR	1.11 (1.08-1.51)	<0.005	1.06 (1.03-1.10)	<0.005
Total protein	0.80 (0.66-0.97)	0.024	0.78 (0.63-0.97)	0.024

CI, confidence interval; CRP, C-reactive protein; HR, hazard ratio; M0, no metastasis; M1 (HEP), liver metastasis; NLR, neutrophil-to-lymphocyte ratio.