Table 4.

Databases with genomic data and where to check for relevance of alterations

Database	Comments
Cancer Genome Atlas (TCGA)	Large database including cancer-associated genomic alterations of >20 000 cancer patients
International Cancer Genome Consortium (ICGC)	Global initiative to build a large database of genomic alterations in the most common tumor types
OncoKB	Memorial Sloan Kettering Cancer Centre precision oncology database including link to FDA levels of evidence
MyCancerGenome	Large database including cancer-associated genomic alterations of almost 100 000 tumor samples
CIViC	Clinical interpretation of variants in cancer, open access open source, community driven
COSMIC	Large catalogue of somatic cancer mutations including data from >37 000 genomes
ClinVar	Freely accessible, public archive of reports of the relationships among human variations and phenotypes, with supporting evidence
Online Mendelian Inheritance in Man (OMIM)	Comprehensive, authoritative compendium of human genes and genetic phenotypes
VarSome	Variant knowledge community, data aggregator and variant data discovery tool
Breast Cancer Information Core (BIC) Database	Large BRCA1 and BRCA2 gene mutation database
ARUP BRCA1 and BRCA2 mutation databases	Provides information on BRCA1 and BRCA2 gene mutations and their impact on risk of developing breast cancer, ovarian cancer and certain other cancers. Two types of databases are provided. One is a list of mutations curated from critical review of literature and family studies. The other provides in silico prediction of risk to help understand variants of unknown significance

FDA, Food and Drug Administration.