Table 1.
The number of incidence cases and ASIR of Alzheimer's disease and other dementias in 1990 and 2019 and its EAPC.
| 1990 | 2019 | 1990–2019 | |||
|---|---|---|---|---|---|
| Characteristics |
Incidence cases (*10∧6) (95% UI) |
ASIR (per 100,000) (95% UI) |
Incidence cases (*10∧6) (95% UI) |
ASIR (per 100,000) (95% UI) |
EAPC of ASIR (95% CI) |
| Global | 2.92 (2.49–3.37) | 93.58 (80.12–106.7) | 7.24 (6.22–8.23) | 94.99 (81.59–107.86) | 0.06 (0.03 to 0.08) |
| Gender | |||||
| Males | 1.01 (0.86–1.17) | 81.03 (68.55–93) | 2.69 (2.27–3.09) | 83.67 (71.06–95.65) | 0.13 (0.1 to 0.16) |
| Females | 1.91 (1.63–2.2) | 101.64 (87.34–115.71) | 4.55 (3.93–5.16) | 103.45 (89.24–117.15) | 0.06 (0.04 to 0.08) |
| Sociodemographic index | |||||
| Low | 0.11 (0.1–0.13) | 78.7 (67.02–90.5) | 0.27 (0.24–0.31) | 76.97 (66.01–87.9) | −0.07 (−0.1 to −0.05) |
| Low-middle | 0.3 (0.25–0.34) | 77.31 (65.89–88.63) | 0.82 (0.7–0.94) | 77.07 (65.7–88.14) | −0.03 (−0.06 to −0.01) |
| Middle | 0.61 (0.52–0.71) | 88.38 (74.76–101.4) | 1.9 (1.62–2.18) | 93.29 (79.52–106.76) | 0.11 (0.08 to 0.15) |
| High-middle | 0.84 (0.71–0.99) | 97.55 (82.44–111.71) | 2.01 (1.71–2.31) | 101.68 (86.58–116.12) | 0.13 (0.11 to 0.16) |
| High | 1.05 (0.9–1.21) | 99.64 (86.19–113.09) | 2.23 (1.93–2.51) | 100.57 (87.24–113.37) | 0.11 (0.08 to 0.14) |
| 21 GBD regions | |||||
| Central Asia | 0.04 (0.03–0.04) | 101.63 (86–116.8) | 0.05 (0.04–0.06) | 102.74 (87.44–117.42) | 0.05 (0.02 to 0.08) |
| Central Europe | 0.13 (0.11–0.16) | 104.04 (87.55–119.69) | 0.24 (0.2–0.28) | 106.31 (89.8–121.85) | 0.09 (0.08 to 0.1) |
| Eastern Europe | 0.23 (0.19–0.28) | 98.28 (81.88–113.72) | 0.36 (0.3–0.42) | 101.93 (85.52–116.99) | 0.17 (0.13 to 0.2) |
| Australasia | 0.02 (0.02–0.02) | 96.01 (82.52–109.28) | 0.05 (0.04–0.06) | 93.84 (80.46–106.76) | −0.06 (−0.07 to −0.04) |
| High-income Asia Pacific | 0.17 (0.14–0.2) | 96.86 (83.48–110.97) | 0.63 (0.54–0.71) | 108.9 (93.99–123.75) | 0.48 (0.45 to 0.52) |
| High-income North America | 0.42 (0.35–0.48) | 111.1 (94.6–126.89) | 0.74 (0.66–0.82) | 105.77 (93.77–116.93) | −0.04 (−0.09 to 0) |
| Southern Latin America | 0.04 (0.03–0.04) | 92.71 (78.34–106.93) | 0.08 (0.07–0.09) | 95.18 (80.96–109.17) | 0.1 (0.09 to 0.12) |
| Western Europe | 0.57 (0.49–0.65) | 93.49 (81.02–105.5) | 1.01 (0.86–1.16) | 91.52 (78.13–104.43) | −0.05 (−0.07 to −0.03) |
| Andean Latin America | 0.01 (0.01–0.02) | 80.97 (68.97–93.44) | 0.04 (0.04–0.05) | 83.48 (71.56–95.52) | 0.11 (0.08 to 0.13) |
| Caribbean | 0.02 (0.01–0.02) | 77.69 (66.39–89.43) | 0.04 (0.04–0.05) | 78.42 (67.22–89.79) | 0.03 (0 to 0.05) |
| Central Latin America | 0.05 (0.05–0.06) | 83.83 (71.35–96.9) | 0.18 (0.16–0.21) | 82.9 (70.84–95.18) | 0 (−0.03 to 0.03) |
| Tropical Latin America | 0.07 (0.06–0.08) | 102.3 (88.03–116.99) | 0.24 (0.21–0.27) | 104.09 (90.49–118.13) | 0.09 (0.07 to 0.1) |
| North Africa and Middle East | 0.13 (0.11–0.15) | 109.25 (92.75–125.03) | 0.36 (0.31–0.41) | 110.17 (93.94–125.62) | 0.04 (0.02 to 0.06) |
| South Asia | 0.22 (0.19–0.25) | 64.17 (54.61–73.81) | 0.68 (0.58–0.78) | 63.63 (54.2–72.95) | −0.04 (−0.1 to 0.01) |
| East Asia | 0.53 (0.45–0.62) | 90.36 (76.22–104.02) | 1.86 (1.57–2.15) | 103.32 (87.6–118.29) | 0.33 (0.27 to 0.39) |
| Oceania | 0 (0–0) | 88.33 (74.28–101.85) | 0 (0–0) | 86.26 (73.29–98.98) | −0.09 (−0.12 to −0.06) |
| Southeast Asia | 0.15 (0.13–0.17) | 84.62 (72.1–97.18) | 0.4 (0.35–0.46) | 84.8 (72.56–96.84) | 0.02 (−0.02 to 0.06) |
| Central Sub-Saharan Africa | 0.01 (0.01–0.01) | 96.41 (83.03–110.18) | 0.03 (0.03–0.04) | 98.35 (85.22–112.11) | 0.08 (0.07 to 0.09) |
| Eastern Sub-Saharan Africa | 0.04 (0.03–0.05) | 85.81 (73.42–98.23) | 0.09 (0.08–0.11) | 85.08 (73.42–96.76) | −0.02 (−0.05 to 0.02) |
| Southern Sub-Saharan Africa | 0.02 (0.02–0.02) | 90.15 (77.17–103.33) | 0.04 (0.03–0.04) | 89.95 (77.28–102.68) | −0.01 (−0.06 to 0.04) |
| Western Sub-Saharan Africa | 0.04 (0.04–0.05) | 75.34 (64.05–86.53) | 0.09 (0.08–0.11) | 73.47 (62.61–83.94) | −0.11 (−0.18 to −0.03) |
ASIR, age-standardized incidence rate; EAPC, estimated annual percent change; SDI, sociodemographic index.