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. 2022 Oct 10;10:1014498. doi: 10.3389/fcell.2022.1014498

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Copyright © 2022 Pladevall-Morera and Zylicz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mouse embryonic development is coordinated with metabolic and epigenetic changes. (A) Schematic illustration of early mouse embryogenesis from fertilization until implantation (E0.5-E6.5) and crucial developmental events. The embryo moves through different environments within the female reproductive system and several metabolites are essential for embryo development in different stages. (B) Oxygen availability and consumption vary depending on the stage of embryonic development. Furthermore, the embryo undergoes metabolic and epigenetic reprogramming during the first days of development. EPI, epiblast; H3K9me2, dimethylation of histone H3 lysine 9; ICM, inner cell mass; PGC, primordial germ cells; PrE, primitive endoderm; PS, primitive streak; TE, trophectoderm; ZGA/EGA, zygotic genome activation/embryonic genome activation.