Table 4.
Relationship between sputum eosinophils and AHR in asthmatic populations.
Asthma population | Patient number (N), [REF] | Allergen | Methacholine Mean PC20 mg/ml | Mean (SE) sputum Eos (%) | Correlation |
---|---|---|---|---|---|
Mild intermittent (recent diagnosis) | N = 30, [Boulet LP] | Cat, dog, house-dust mite or cockroach | 4.9 (2.3) | 0.9 (0.5–2.2) | NO |
Mild intermittent (diagnosis > 5 years) | N = 30, [Boulet LP] | Cat, dog, house-dust mite or cockroach | 2.9 (2.2) | 0.9 (0.4–1.9) | NO |
Mild persistent Off ICS treatment (6 month) |
N = 30, [Foresi A] | House-dust mite | 0.42 to 2.6 mmol | 16.7 ± 5.06 | YES r =-0.52 |
Mild to moderate persistent Off ICS treatment (1 month) |
N = 28 [Crimi E] | House-dust mite or pet dandruff | 0.099 | 8.5± 1.9 | NO R = 0.24 |
Mild to moderate naïve Off ICS treatment (6 weeks) |
N = 118,[ R. Louis] | House-dust mites, grass, birch, weed, cat and dog dander, mold mixture | 1.10 (0.03–16) | 10.9 (13.6) | YES R =-0.40 |
Mild to moderate naïve Off ICS treatment (3 months) |
N = 35 [A Jatakanon] | Non known | 0.52 (1.23) | 6.8 (1.2) | YES r = −0.40 |