Table 1.
Characterization of the main myeloid cell populations
| Kinetic families | Population characteristics | Phenotypic families | Subsets characteristics | Cell population∗ | References |
|---|---|---|---|---|---|
| KF-I | HLA-DR+, CD64hi, CD86hi, CD11bhi | 1 | CD14lo, CD32mid | classical monocytes | Nakaya et al. 7; Tsang et al. 8; Trautmann and Sekaly9; Mooney et al.10; Reimann et al.11; Estes et al.12; Sanders and Moore13; De Taeye et al.14; Sliepen et al.15; Brouwer et al.16 |
| 3 | CD14lo, CD32+ | ||||
| 10 | CD14lo, CD32hi | ||||
| 15 | CD14+, CD1clo | MoDC | |||
| 25 | CD14+, CD1clo | ||||
| 19 | CD14lo, CD16+, CD11c+ | non-classical monocytes | |||
| 22 | CD14+, CD16+, CD11c+ | intermediate monocytes | |||
| KF-II | HLA-DRhi, CD32hi, CD64hi, CD86hi, CD11bhi | 2 | CD14+, CD1clo | MoDC | Reimann et al.11; Zhang et al.18 |
| HLA-DR+ | 20 | FceRIhi, CD32hi, CD86hi, CD4lo | putative cDC2 | Reimann et al.11; De Taeye et al.14; Wines et al.17; Calabro et al.19 | |
| 9 | CD1c+, FceRIhi, CD32hi, CD86hi, CD4lo | cDC2 | |||
| 24 | |||||
| HLA-DRmid, CD11c+, CD16+, CD32+ | 28 | CADM1+ | cDC1 like DC | De Taeye et al. 14; Wines et al.17 | |
| KF-III | HLA-DRvar, CD11c+, CD16+, CD32+ | 4 | / | DC | / |
| 5 | |||||
| HLA-DRlo, CD11chi, CD16hi | 6 | / | DC | / | |
| 7 | |||||
| 14 | |||||
| HLA-DRlo, CD11chi, CD16lo | 18 | CD11alo | |||
| KF-IV | HLA-DR+, CD32hi, CD64hi, CD86hi, CD11bhi | 8 | CD14lo | classical monocytes | Nakaya et al.7; Tsang et al.8; Trautmann and Sekaly9; Mooney et al.10; Reimann et al.11; Estes et al.12; Sanders and Moore13; De Taeye et al.14; Sliepen et al.15; Brouwer et al.16 |
| HLA-DRvar, CD11c+, CD16+, CD32+ | 17 | / | DC | / | |
| KF-V | HLA-DR+ | 11 | CADM1+, CD1c−, CD172alo, CD16lo | cDC1 | De Taeye et al.14; Wines et al.17 |
| 21 | CD1c+, FceRIhi, CD86mid CD123–, CD4− | immature cDC2 | Pauthner et al.20 | ||
| KF-VI | HLA-DRlo, CD123+ | 12 | CD11ahi, CD4+, CCR5+ | pDC | Reimann et al.11; Estes et al.12; Wines et al.17; Pauthner et al.20; Calabro et al.19; O’Hagan et al.21; Rosenbaum et al.22; Anderson et al.23; Sanders et al.24 |
| 23 | CD11avar, CD4lo, CCR5var | pDC/blood DC precursor | |||
| KF-VII | HLA-DRlo, CD14+, CD11b+, CD64+, CD11c−, CD16− | 13 | CCR5+, CXCR4+, CD62L+ | putative macrophages | / |
| HLA-DRmid, CD14+, CD11b−, CD64−, CD11c+, CD16+ | 27 | CCR5+, CXCR4+, CD62L+ | putative macrophages | / | |
| KF-VIII | HLA-DRlo, CD11chi, CD16hi | 16 | CADM1+ | cDC1 like DC | De Taeye et al.14; Wines et al.17 |
| 26 |
The phenotypic composition of each kinetic family is detailed. The main phenotypic characteristics used to identify cell populations according to the expression profile shown in the heatmap (Figure 3) are indicated. ∗proposal of cell annotation. Absence of data were indicated with /.