Fig. 13.

Gene transfection as a modification strategy of donor cells. (A) Pattern diagram of H19-Exos playing a protective role in cartilage. (B) Quantitative analysis of SA-β-Gal staining of chondrocytes and protein and mRNA levels of chondrocyte-associated genes. (C, D) Gross, MRI images and International Cartilage Repair Society (ICRS) score of regenerated tissues at weeks of 4 and 8, (n = 5). (E, F) Histological staining and Wakitani score after 4 weeks of cartilage repair (n = 5). Reproduced under the terms of the CC-BY 4.0 [29]. Copyright 2021, The Authors, published by Wiley-VCH.