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. 2022 Oct 4;3(10):100763. doi: 10.1016/j.xcrm.2022.100763

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Detail on the increase of the biological pathway of cholesterol biosynthesis in liver

(A) Pathway visualization based on Reactome and complemented with details from KEGG and the literature. Tiles illustrate log-fold change values of T2D compared with CTRL in liver. Proteins leading the increase of the pathway are marked as driving and are shown in black font and colored tiles. Proteins participating in the pathway and identified from MS proteomics, but not marked as leading edges, are in white tiles, whereas those in gray were not identified in this analysis.

(B) Detailed comparison of the abundance of driving proteins between T2D and CTRL in liver.